Yes — with 90.3 GB to spare

Mistral 7B Instruct v0.3 at Q4_K_M fits your Ryzen AI Max+ 395 · 128 GB entirely in unified memory at 8K context, at an estimated 35 tokens per second. There is room for its full 32K window.

Fully in unified memory 8K context Q4_K_M · 4.1 GB Apache 2.0 Released May 2024

Old but extremely well behaved, and permissively licensed for commercial use.

What hardware do I need for Mistral 7B Instruct v0.3? →

The VRAM budget

weights 4.1 GB
Weights 4.1 GB KV cache @ 8K 1.00 GB Runtime overhead 0.6 GB Free 90.3 GB of 96.0 GB

Quantisation ladder

QuantWeightsTotal @ 8KMax contextTok/sQualityFit
F16 13.5 GB 15.1 GB 32K 11 Reference Long context
Q8_0 7.2 GB 8.8 GB 32K 20 −0.1% ppl Long context
Q6_K 5.5 GB 7.1 GB 32K 26 −0.4% ppl Long context
Q5_K_M 4.8 GB 6.4 GB 32K 30 −0.8% ppl Long context
Q4_K_M 4.1 GB 5.7 GB 32K 35 −1.9% ppl Recommended
Q3_K_M 3.3 GB 4.9 GB 32K 43 −5.4% ppl Long context
Q2_K 2.8 GB 4.4 GB 32K 51 −15% ppl Long context

Quality is the published perplexity delta against f16 weights. Max context assumes an f16 KV cache; q8_0 roughly doubles it.

How to run it

terminal
$ ollama pull mistral:7b
$ OLLAMA_CONTEXT_LENGTH=8192 \
    ollama run mistral:7b

The default. One binary, a model registry, an OpenAI-compatible port. More on Ollama.

01Download is 4.1 GB. Keep it on an SSD — a first load off a spinning disk takes minutes.
02macOS caps what the GPU may wire down at about 96.0 GB of 128 GB. Raising it with iogpu.wired_limit_mb is possible, and risky.
03There is room to go to the model's full 32K context on this card.
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