Yes — with 31.0 GB to spare

Gemma 3 27B at Q4_K_M fits your Ryzen AI Max+ 395 · 64 GB entirely in unified memory at 8K context, at an estimated 9.3 tokens per second. There is room for its full 128K window.

Fully in unified memory 8K context Q4_K_M · 15.4 GB Gemma Terms of Use Released Mar 2025 Vision

The 2025 single-GPU generalist with vision. Its Gemma-licence terms are the reason to prefer Gemma 4 now.

What hardware do I need for Gemma 3 27B? →

The VRAM budget

weights 15.4 GB
Weights 15.4 GB KV cache @ 8K 1.03 GB Runtime overhead 0.6 GB Free 31.0 GB of 48.0 GB

Quantisation ladder

QuantWeightsTotal @ 8KMax contextTok/sQualityFit
Q8_0 27.1 GB 28.7 GB 128K 5.3 −0.1% ppl Long context
Q6_K 20.9 GB 22.6 GB 128K 6.8 −0.4% ppl Long context
Q5_K_M 18.1 GB 19.7 GB 128K 7.9 −0.8% ppl Long context
Q4_K_M 15.4 GB 17.0 GB 128K 9.3 −1.9% ppl Recommended
Q3_K_M 12.5 GB 14.1 GB 128K 11 −5.4% ppl Long context
Q2_K 10.7 GB 12.3 GB 128K 13 −15% ppl Long context

Quality is the published perplexity delta against f16 weights. Max context assumes an f16 KV cache; q8_0 roughly doubles it. This model interleaves sliding-window layers (1024 tokens, 1 global in 6), which is why its cache barely grows with context.

How to run it

terminal
$ ollama pull gemma3:27b
$ OLLAMA_CONTEXT_LENGTH=8192 \
    ollama run gemma3:27b

The default. One binary, a model registry, an OpenAI-compatible port. More on Ollama.

01Download is 15.4 GB. Keep it on an SSD — a first load off a spinning disk takes minutes.
02macOS caps what the GPU may wire down at about 48.0 GB of 64 GB. Raising it with iogpu.wired_limit_mb is possible, and risky.
03There is room to go to the model's full 128K context on this card.
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