Yes — with 39.7 GB to spare

Gemma 3 12B at Q4_K_M fits your M4 Pro · 64 GB entirely in unified memory at 8K context, at an estimated 22 tokens per second. There is room for its full 128K window.

Fully in unified memory 8K context Q4_K_M · 6.9 GB Gemma Terms of Use Released Mar 2025 Vision

Strong multilingual chat with images, sized for 12–16 GB cards. Gemma 4 12B is the same size and better.

What hardware do I need for Gemma 3 12B? →

The VRAM budget

weights 6.9 GB
Weights 6.9 GB KV cache @ 8K 0.81 GB Runtime overhead 0.6 GB Free 39.7 GB of 48.0 GB

Quantisation ladder

QuantWeightsTotal @ 8KMax contextTok/sQualityFit
F16 22.7 GB 24.1 GB 128K 6.7 Reference Long context
Q8_0 12.1 GB 13.5 GB 128K 13 −0.1% ppl Long context
Q6_K 9.3 GB 10.7 GB 128K 16 −0.4% ppl Long context
Q5_K_M 8.1 GB 9.5 GB 128K 19 −0.8% ppl Long context
Q4_K_M 6.9 GB 8.3 GB 128K 22 −1.9% ppl Recommended
Q3_K_M 5.6 GB 7.0 GB 128K 27 −5.4% ppl Long context
Q2_K 4.8 GB 6.2 GB 128K 32 −15% ppl Long context

Quality is the published perplexity delta against f16 weights. Max context assumes an f16 KV cache; q8_0 roughly doubles it. This model interleaves sliding-window layers (1024 tokens, 1 global in 6), which is why its cache barely grows with context.

How to run it

terminal
$ pip install mlx-lm
$ mlx_lm.generate --model mlx-community/gemma-3-12b-it-4bit \
    --max-tokens 512 --prompt "Hello"

Apple's own array framework. The fastest path on Apple Silicon. More on MLX.

01Download is 6.9 GB. Keep it on an SSD — a first load off a spinning disk takes minutes.
02macOS caps what the GPU may wire down at about 48.0 GB of 64 GB. Raising it with iogpu.wired_limit_mb is possible, and risky.
03There is room to go to the model's full 128K context on this card.
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