Yes — with 53.2 GB to spare

DeepSeek-R1-Distill-Llama 70B at Q4_K_M fits your Ryzen AI Max+ 395 · 128 GB entirely in unified memory at 8K context, at an estimated 3.6 tokens per second. There is room for its full 128K window.

Fully in unified memory 8K context Q4_K_M · 39.7 GB MIT / Llama 3.3 Community Released Jan 2025

The strongest of the R1 distills, and the one that most needs 48 GB or more.

What hardware do I need for DeepSeek-R1-Distill-Llama 70B? →

The VRAM budget

weights 39.7 GB
Weights 39.7 GB KV cache @ 8K 2.50 GB Runtime overhead 0.6 GB Free 53.2 GB of 96.0 GB

Quantisation ladder

QuantWeightsTotal @ 8KMax contextTok/sQualityFit
Q8_0 69.9 GB 73.0 GB 81K 2.0 −0.1% ppl Long context
Q6_K 53.9 GB 57.0 GB 128K 2.7 −0.4% ppl Long context
Q5_K_M 46.6 GB 49.7 GB 128K 3.1 −0.8% ppl Long context
Q4_K_M 39.7 GB 42.8 GB 128K 3.6 −1.9% ppl Recommended
Q3_K_M 32.1 GB 35.2 GB 128K 4.5 −5.4% ppl Long context
Q2_K 27.5 GB 30.6 GB 128K 5.2 −15% ppl Long context

Quality is the published perplexity delta against f16 weights. Max context assumes an f16 KV cache; q8_0 roughly doubles it.

How to run it

terminal
$ ollama pull deepseek-r1:70b
$ OLLAMA_CONTEXT_LENGTH=8192 \
    ollama run deepseek-r1:70b

The default. One binary, a model registry, an OpenAI-compatible port. More on Ollama.

01Download is 39.7 GB. Keep it on an SSD — a first load off a spinning disk takes minutes.
02macOS caps what the GPU may wire down at about 96.0 GB of 128 GB. Raising it with iogpu.wired_limit_mb is possible, and risky.
03There is room to go to the model's full 128K context on this card.
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